Jiangang Chen, MD, PhD researches potential environmental impacts on human reproduction, with a special interest in effects of endocrine disruptors (EDS) on the homeostasis of endogenous hormones. A considerable part of his research has been focused on a wide variety of synthetic compounds with intrinsic hormonal activity that may have adverse effects on human health. Exposure to EDS may change the balance of endogenous hormones, i.e. between estrogen signaling and androgen signaling; and thus, may contribute to the pathology of many hormone responsive diseases, including prostate and breast cancers.
Many of these compounds are manufactured and released in large quantities into the environment. While the EDS properties of many pesticides have been well documented and their applications are tightly regulated, the toxicity and human exposure levels to the enormous numbers of non-pesticide synthetic chemicals are largely unclear. These compounds are ubiquitous in our daily life, either present in many personal care products or potentially leaching out of plastics, carpets and food packages.
In addition, using animal models, his group studies the in utero exposure of EDS during pregnancy to elucidate if early exposure could change the trajectory of the fetus in later life, which could considerably increase social and medical burdens.
Li, H.X., Nakajima, S.T., Chen, J., Todd, H.E., Overstreet, J.W., and Lasley, B.L. (2001) Differences in Hormonal Characteristics of Conceptive versus Non-conceptive Menstrual Cycles. Fertility and Sterility: 75(3): 549-53. PMID: 11239540
Moran, F.M., Tarara, R., Chen, J., Santos, S., Cheney, A., Overstreet, J.W., and Lasley, B.L.(2001) Effect of Dioxin on Ovarian Function in the Cynomolgus Macaque (M. Fascicularis). Reproductive Toxicology: 15(4): 377-83. PMID: 11489593
Natarajan, K., Overstreet, J.W., Rogers, J.M., Denison, M.S., Chen, J., Lohstroh, P.N., McConnel, D.S., and Lasley, B.L. (2002) Detection of Xenoestrogens in Serum after Immunoprecipitation of Endogenous Steroidal Estrogens. Environmental Health Perspectives: 110 (8): 791-5. PMID: 12153760
Moran, F.M., Lohstroh, P., VandeVoort, C.A., Chen, J., Overstreet, J.W., Conley, A.J., and Lasley, B.L. (2003) Exogenous Steroid Substrate Modifies the Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on Estradiol Production of Human Lluteinized Granulosa Cells in vitro. Biology of Reproduction: 68(1): 244-51. PMID: 12493720
Chen, J., Laughlin, L., Overstreet, J.W., and Lasley, B.L. (2003) The Effect of 2,3,7,8-tetrachlorodibenzo-pdioxin on Chorionic Gonadotropin (CG) Activity. Toxicology: 186(1-2): 21-31. PMID: 12604168
Chen, J., Thirkill, T.L., Overstreet, J.W., Lasley, B.L., and Douglas, G.C. (2003) Effect of 2,3,7,8- tetrachlorodibenzo-p-dioxin (TCDD) on Chorionic Gonadotropin (CG) Secretion by Human Trophoblasts. Reproductive Toxicology: 17(1): 87-93. PMID: 12507663
Chen, J., Qiu, Q., Lohstroh, P., Overstreet, J.W., and Lasley, B.L. (2003) Hormonal Characteristics in the Early Luteal Phase of Conceptive and Non-conceptive Menstrual Cycles. Journal of the Society for Gynecologic Investigation: 10(1): 27-31. PMID: 12517590
Lohstroh, P.N., Chen, J., Ba, J., Ryan, L.M., Xu, X.P., Overstreet, J.W., and Lasley, B.L. (2003) Bone Health Is Affected By Follicular Phase Length in Female Rotating Shift Workers. Environmental Health Perspectives: 111(4): 618-22. (contributed equally) PMID: 12676625
Chen, J. Douglas, G.C., Thirkill, T.L., Lohstroh, P.N., Bielmeier, S.R., Narotsky, M.G., Best, D.S., Harrison, R.A., Natarajan, K., Pegram, R.A., Overstreet, J.W. and Lasley, B.L. (2003) Effect of Bromodichloromethane on Chorionic Gonadotrophin Secretion by Human Placental Trophoblast Cultures. Toxicological Sciences: 76(1): 75-82. PMID: 12970577
Chen, J., Thirkill,T.L., Lohstroh, P.N., Bielmeier, S.R., Narotsky, M.G., Best, D.S., Harrison, R.A., Natarajan, K., Pegram, R.A., Overstreet, J.W., Lasley, B.L., and Douglas, G.C. (2004) Bromodichloromethane Inhibits Human Placental Trophoblast Differentiation. Toxicological Sciences: 78(1): 166-74. PMID: 14691210
Chen, J., Sowers, M.R., Moran, F.M., McConnell, D.S., Gee, N.A., Greendale, G.A., Whitehead, C., Kasim-Karakas, S.E., and Lasley, B.L. (2006) Circulating Bioactive Androgens in Midlife Women. Journal of Clinical Endocrinology and Metabolism: 91(11): 4387-94. PMID: 16940455
Chen, J., Ahn, K.C., Gee, N.A., Gee, S.J., Hammock, B.D., and Lasley, B.L. (2007) Antiandrogenic Properties of Parabens and Other Phenolic Containing Small Molecules in Personal Care Products. Toxicology And Applied Pharmacology: 221(3): 278-84. PMID: 17481686
Yon, L., Chen, J., Moran, P., and Lasley, B.L. (2008) An Analysis of the Androgens of Musth in the Asian Bull Elephant (Elephas maximus). General and Comparative Endocrinology: 155(1):109-15. PMID: 17466989
Chen, J., Ahn, K.C., Gee, N.A., Mohamed, M.I., Duleba, A.J., Zhao, L., Gee, S.J., Hammock, B.D., and Lasley, B.L. (2008) Triclocarban Enhances Ttestosterone Action: A new Type of Endocrine Disruptor? Endocrinology: 149(3):1173-9. PMID: 18048496
Ahn, K.C., Zhao B., Chen, J., Cherednichenko, G., Sanmarti, E., Denison, M.S., Lasley, B., Pessah, IN., Kültz, D., Chang, D.P.Y., Gee, S.J., Hammock, B.D. (2008) In vitro Biologic Activities of the Antimicrobials Triclocarban, Iits Analogs, and Triclosan in Bioassay Screens: Rreceptor-based Bioassay Screens. Environmental Health Perspectives: 116(9):1203-10. PMID: 18795164
Duleba, A.J., Ahmed, M.I., Sun, M., Gao, A.C., Villanueva, J., Conley, A.J., Turgeon, J.L., Benirschke, K., Gee, N.A., Chen, J., Green, P.G., and Lasley. B.L. (2010) Effects of triclocarban on intact immature male rat: augmentation of androgen action. Reproductive Sciences. Accepted.